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Each 5 gm contains:
Composition:
Triclosan, Silica, Special Flavour.
Indications :
Twice Brushing with Dr. Dentist, gently removes tough stain,
long lasting mint flavour keeps mouth clean & fresh, no
harsh aprasives or bleach.
Description:
Triclosan is a broad-spectrum antibacterial agent that
inhibits bacterial fatty acid synthesis at the
enoyl-acyl carrier protein reductase (FabI)
step. Resistance to triclosan in Escherichia
coli is acquired through a missense mutation
in the fabI gene that leads to the
expression of FabI[G93V]. The specific activity
and substrate affinities of FabI[G93V] are similar
to FabI. Two different binding assays
establish that triclosan dramatically
increases the affinity of FabI for NAD+. In
contrast, triclosan does not increase the binding of NAD+
to FabI[G93V]. The x-ray crystal structure of the
FabI-NAD+-triclosan complex confirms that
hydrogen bonds and hydrophobic interactions
between triclosan and both the protein and the NAD+
cofactor contribute to the formation of a stable ternary
complex, with the drug binding at the enoyl
substrate site. These data show that the
formation of a noncovalent "bi-substrate" complex
accounts for the effectiveness of triclosan as a
FabI inhibitor and illustrates that mutations
in the FabI active site that interfere with
the formation of a stable FabI-NAD+-triclosan
ternary complex acquire resistance to the
drug.
Dosage :
As per the physician’s advice or Dentist Doctor’s
advices.
Presentations :
100 gm
MRP
Retailer
Stockist
50.00
40.00
36.00
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