|
Each tablet contains:
Composition:
Erythromycin............................................................….250
mg
Erythromycin........................................................…….500
mg
Indications:
Acute bacterial pharyngitis, tonsillitis, sinusitis,
otitis, mastoiditis, epiglottitis, bronchitis,
pneumonia, erysipelas, whooping cough, cellulitis,
carbuncle, pyoderma, diphtheria, Legionnaire’s
disease, urogenital.
Description:
Erythromycin prevents
bacteriafrom
growing by interfering with their
protein synthesis.
Erythromycin binds to the 23s rRNA molecule in the
50S of the bacterial
ribosome,
blocking the exit of the growing peptide chain thus
inhibiting the translocation of
peptides.
Side-effects
Gastrointestinal disturbances such as
diarrhea,
nausea,
abdominal pain
and
vomiting
are fairly common so it tends not to be prescribed
as a first-line drug. However, erythromycin may be
useful in treating
gastroparesis
due to this pro-motility effect. Intravenous
erythromycin may also be used in
endoscopy
as an adjunct to clear
gastric
contents.
More serious side-effects, such as reversible
deafness
are rare. Allergic reactions, while uncommon, may
occur, ranging from
urticaria
to
anaphylaxis.
Cholestasis,
Stevens-Johnson
syndrome and
toxic epidermal
necrolysis are some other rare side
effects that may occur.
Erythromycin has been shown to increase the
probability of
pyloric stenosis
in children whose mothers took the drug during the
late stages of pregnancy or while nursing.
Contraindications
Earlier case reports on sudden death prompted a
study on a large cohort that confirmed a link
between erythromycin,
ventricular
tachycardia and sudden cardiac death in
patients also taking drugs that prolong the
metabolism of erythromycin (like
verapamil
or
diltiazem)
by interfering with
CYP3A4
(Ray et al 2004). Hence, erythromycin should
not be administered in patients using these drugs,
or drugs that also prolong the
QT time.
Other examples include
terfenadine
(Seldane, Seldane-D),
astemizole
(Hismanal),
cisapride
(Propulsid, withdrawn in many countries for
prolonging the QT time) and
pimozide
(Orap).
Dosage :
As per the physician’s advice.
Presentations :
10 tablets
MRP Retailer
Stockist
29.95 23.96
21.56
55.86 44.68
40.21
|
