Famexavir
TM
250 mg / 500 mg
Each tablet contains:
Composition:
Famciclovir
........................................................................250
mg
Famciclovir
........................................................................500
mg
Indications:
Herpes Zoster: Famexavir (famciclovir) is indicated for
the treatment of acute herpes zoster (shingles),
treatment or suppression of recurrent genital herpes in
immunocompetent patients, and treatment of recurrent
mucocutaneous herpes simplex infections in HIV-infected
patients.
Description:
Famciclovir undergoes
rapid biotransformation to the active compound,
penciclovir, which is phosphorylated by viral thymidine
kinase in HSV-1, HSV-2, and VZV-infected cells to a
monophosphate form; this is then converted to
penciclovir triphosphate and competes with
deoxyguanosine triphosphate to inhibit HSV-2 polymerase
(eg, herpes viral DNA synthesis/replication is
selectively inhibited)
Warnings/Precautions
Has not been established for use in initial episodes
of genital herpes, patients with ophthalmic or
disseminated zoster, or in immunocompromised patients
with herpes zoster. Dosage adjustment is required in
patients with renal insufficiency. Tablets contain
lactose; do not use with galactose intolerance, severe
lactase deficiency, or glucose-galactose malabsorption
syndromes. Safety and efficacy have not been established
in children <18 years of age.
Contraindications
Hypersensitivity to famciclovir, penciclovir, or any component of the
formulation
Dosage and Administration
Adults : Herpes zoster: 250 mg three times daily for 7
days or 750 mg once daily for 7 days (500 mg three times
daily for 10 days in immunocompromised). Genital herpes:
First episode: 250 mg three times daily for 5 days;
recurrent infection, 125 mg twice daily for 5 days (500
mg twice daily for 7 days in all episodes in
immunocompromised). Suppression of recurrent genital
herpes: 250 mg twice daily (500 mg twice daily in HIV
patients) interrupted every 6-12 months. Children: Not
recommended
Interactions
Uricosurics: probenicid possibly reduces famciclovir
excretion thereby increasing plasma concentration
Dosage: As per
the physician’s advice.
Presentations:
MRP Retailer Stockist
10 tablets
315.00 252.00
226.80
7 tablets 280.75
224.60 202.14
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